40S ribosomal protein S15a
40S ribosomal protein S15a is a protein that in humans is encoded by the RPS15A gene.
Quick Facts RPS15A, Available structures ...
| RPS15A |
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| Available structures |
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| PDB | Ortholog search: PDBe RCSB |
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| List of PDB id codes |
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4UG0, 4V6X, 5A2Q, 5AJ0, 4KZY, 3J7R, 4D61, 4KZX, 4D5L, 4V5Z, 5FLX, 4UJD, 3J7P, 4KZZ, 4UJE, 4UJC |
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| Identifiers |
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| Aliases | RPS15A, S15a, ribosomal protein S15a, DBA20 |
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| External IDs | OMIM: 603674 MGI: 2389091 HomoloGene: 128982 GeneCards: RPS15A |
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| Gene location (Human) |
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 | | Chr. | Chromosome 16 (human) |
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| | Band | 16p12.3 | Start | 18,781,295 bp |
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| End | 18,790,383 bp |
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| Gene location (Mouse) |
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 | | Chr. | Chromosome 7 (mouse) |
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| | Band | 7|7 F1 | Start | 118,104,372 bp |
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| End | 118,116,188 bp |
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| Gene ontology |
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| Molecular function | • structural constituent of ribosome
• GO:0001948 protein binding
• RNA binding
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| Cellular component | • cytoplasm
• cytosol
• ribosome
• membrane
• extracellular exosome
• mitochondrion
• nucleoplasm
• GO:0005578 extracellular matrix
• cytosolic small ribosomal subunit
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| Biological process | • viral transcription
• response to virus
• SRP-dependent cotranslational protein targeting to membrane
• positive regulation of cell cycle
• positive regulation of cell population proliferation
• translational initiation
• nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
• rRNA processing
• protein biosynthesis
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| Sources:Amigo / QuickGO |
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| Orthologs |
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| Species | Human | Mouse |
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| Ensembl | | |
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| UniProt | | |
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| RefSeq (mRNA) | | |
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| RefSeq (protein) | | |
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| Location (UCSC) | Chr 16: 18.78 – 18.79 Mb | Chr 7: 118.1 – 118.12 Mb |
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| PubMed search | | |
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Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S8P family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.
Further reading
- Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins". Biochem. Cell Biol. 73 (11–12): 933–47. doi:10.1139/o95-101. PMID 8722009.
- Chan YL, Olvera J, Paz V, Wool IG (1994). "The primary structure of rat ribosomal protein S15a". Biochem. Biophys. Res. Commun. 200 (3): 1498–504. doi:10.1006/bbrc.1994.1620. PMID 8185605.
- Vladimirov SN, Ivanov AV, Karpova GG, et al. (1996). "Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry". Eur. J. Biochem. 239 (1): 144–9. doi:10.1111/j.1432-1033.1996.0144u.x. PMID 8706699.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Lehner B, Semple JI, Brown SE, et al. (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics. 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Yu Y, Ji H, Doudna JA, Leary JA (2005). "Mass spectrometric analysis of the human 40S ribosomal subunit: native and HCV IRES-bound complexes". Protein Sci. 14 (6): 1438–46. doi:10.1110/ps.041293005. PMC 2253395. PMID 15883184.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
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