ZBTB7B

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Zinc finger and BTB domain-containing protein 7B is a protein that in humans is encoded by the ZBTB7B gene. ZFP67 is an early growth response gene that encodes a zinc finger-containing transcription factor that binds to the promoter regions of type I collagen genes (e.g. COL1A1; MIM 120150) and has a role in development.[supplied by OMIM]

Quick Facts Identifiers, Aliases ...

ZBTB7B
Identifiers
Aliases	ZBTB7B, THPOK, ZBTB15, ZFP-67, ZFP67, ZNF857B, c-KROX, hcKROX, CKROX, zinc finger and BTB domain containing 7B
External IDs	OMIM: 607646 MGI: 102755 HomoloGene: 7605 GeneCards: ZBTB7B
Gene location (Human) Chr. Chromosome 1 (human) Band 1q21.3 Start 155,002,630 bp End 155,018,522 bp
Gene location (Mouse) Chr. Chromosome 3 (mouse) Band 3 F1|3 39.09 cM Start 89,377,644 bp End 89,394,776 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • DNA binding • GO:0001948 protein binding • metal ion binding • nucleic acid binding • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • GO:0001158 cis-regulatory region sequence-specific DNA binding • protein homodimerization activity • histone deacetylase binding Cellular component • nucleus • nucleoplasm Biological process • multicellular organism development • ectoderm development • cell differentiation • regulation of transcription, DNA-templated • transcription by RNA polymerase II • transcription, DNA-templated • regulation of CD4-positive, alpha-beta T cell differentiation • regulation of CD8-positive, alpha-beta T cell differentiation • positive regulation of transcription by RNA polymerase II • regulation of gene expression • negative regulation of T-helper 17 cell differentiation • lactation • positive regulation of gene expression • response to insulin • positive regulation of CD4-positive, alpha-beta T cell differentiation • negative regulation of CD8-positive, alpha-beta T cell differentiation • positive regulation of insulin receptor signaling pathway • positive regulation of brown fat cell differentiation • adaptive thermogenesis • positive regulation of SREBP signaling pathway • negative regulation of transcription by RNA polymerase II • NK T cell differentiation • negative regulation of gene expression • positive regulation of histone deacetylation • negative regulation of NK T cell proliferation • positive regulation of cold-induced thermogenesis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	51043	22724
Ensembl	ENSG00000160685	ENSMUSG00000028042
UniProt	O15156	Q64321
RefSeq (mRNA)	NM_001252406 NM_001256455 NM_001377451 NM_001377452 NM_001377453 NM_001377454 NM_001377455	NM_009565 NM_001355206 NM_001355211 NM_001355212
RefSeq (protein)	NP_001239335 NP_001243384 NP_001364380 NP_001364381 NP_001364382 NP_001364383 NP_001364384	NP_033591 NP_001342135 NP_001342140 NP_001342141
Location (UCSC)	Chr 1: 155 – 155.02 Mb	Chr 3: 89.38 – 89.39 Mb
PubMed search

Further reading

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• Heegaard AM, Gehron Robey P, Vogel W, et al. (1998). "Functional characterization of the human biglycan 5'-flanking DNA and binding of the transcription factor c-Krox". J. Bone Miner. Res. 12 (12): 2050–60. doi:10.1359/jbmr.1997.12.12.2050. PMID 9421237. S2CID 29523309.
• Ghayor C, Herrouin JF, Chadjichristos C, et al. (2000). "Regulation of human COL2A1 gene expression in chondrocytes. Identification of C-Krox-responsive elements and modulation by phenotype alteration". J. Biol. Chem. 275 (35): 27421–38. doi:10.1074/jbc.M002139200. PMID 10856292.
• Widom RL, Lee JY, Joseph C, et al. (2002). "The hcKrox gene family regulates multiple extracellular matrix genes". Matrix Biol. 20 (7): 451–62. doi:10.1016/S0945-053X(01)00167-6. PMID 11691585.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
• Kypriotou M, Beauchef G, Chadjichristos C, et al. (2007). "Human collagen Krox up-regulates type I collagen expression in normal and scleroderma fibroblasts through interaction with Sp1 and Sp3 transcription factors". J. Biol. Chem. 282 (44): 32000–14. doi:10.1074/jbc.M705197200. PMID 17698844.